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عمومی::
فولینیک اسید
Both the efficacy and toxicity of Fluorouracil may be intensified by combining Fluorouracil with other cytotoxic drugs (e.g. cyclophosphamide, vincristine, methotrexate, cisplatin, doxorubicin), interferon-alpha or folinic acid.
The simultaneous administration of vinorelbine and Fluorouracil/folinic acid can cause severe mucositis (inflammation of the mucous membranes), resulting in death.
Treatment protocol with "low-dose" folinic acid
The chemical and physical stability of Fluorouracil 50 mg/ml solution for injection, combined with trometamol-free folinic acid (as calcium folinate) 10 mg/ml solution for injection in polyisoprene infusion bags, has been demonstrated for two days at 32 °C, if protected from daylight.
A combination of 100 ml Fluorouracil 50 mg/ml solution for injection and 100 ml trometamol-free folinic acid (as calcium folinate) 10 mg/ml solution for injection, achieving the following concentrations, has been tested:
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